Physicochemical Stability of a Quaternary Ammonium-Based Disinfectant Formulation Using CELLOSIZE® as a Rheological Modifier
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The physicochemical stability of disinfectants directly influences their efficacy, safety, and shelf life. The aim of this study was to evaluate the stability of a quaternary ammonium-based disinfectant formulation using hydroxyethyl cellulose as a rheological modifier. The formulation was stored at 10 °C, 20 °C, and 30 °C for 12 months. Hydrogen potential, viscosity, and physical characteristics were determined, together with antimicrobial activity by agar diffusion against Staphylococcus aureus. All determinations were performed in triplicate, and the results were analyzed using descriptive statistics and analysis of variance. The hydrogen potential remained stable under all storage conditions, indicating adequate chemical stability. Viscosity showed a gradual decrease associated with increasing storage time and temperature, with the greatest reduction observed at 30 °C. The formulation maintained its antimicrobial activity throughout the study period, although a slight reduction in inhibition zones was observed under higher thermal stress. It is concluded that the formulation exhibits adequate physicochemical and microbiological stability, and that temperature is the main factor affecting its performance, confirming the suitability of hydroxyethyl cellulose as a rheological modifier for this type of system.
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