It presents academic contributions that explore how scientific knowledge can be articulated with social, cultural, economic and educational processes to generate significant changes in different contexts. The research included proposes models, practices and interdisciplinary approaches that respond to current problems with a vision of collective impact. Through rigorous methodologies and critical analysis, the authors reflect on the role of science as an active agent of transformation, capable of influencing public policies, community practices and social innovation strategies. This issue reaffirms the journal's commitment to a scientific production that not only describes reality, but also contributes to improving it through dialogue among knowledge, inclusion and ethical responsibility.