It convenes research that questions, updates or reformulates traditional theoretical and conceptual frameworks in various disciplines. This issue opens a space for critical reflection and the reconstruction of knowledge in light of new findings, emerging technologies and changing global contexts. The selected papers examine how scientific paradigms evolve in the face of present challenges, from innovative approaches and contrasting methodologies. Included are studies that problematize established concepts, propose new analytical categories and propose alternative horizons for the development of scientific knowledge. This volume seeks to encourage disruptive thinking, epistemological openness and dialogue between academic currents, promoting a science that not only observes, but also reinvents itself to provide more relevant answers to the complex realities of the 21st century.