A compilation of research aimed at understanding how science, in its collaborative and multidimensional nature, can respond to the great challenges of our time. This volume addresses global problems such as climate change, health crises, migration, artificial intelligence and social equity from an interdisciplinary approach, highlighting the need to generate integrative and situated knowledge. The articles included highlight the importance of synergies between disciplines, institutions and cultural contexts to address complex situations with innovative, sustainable and ethically responsible solutions. Through scientific dialogue between different fields of knowledge, this issue promotes a vision of science as a transforming agent, capable of articulating joint responses to the emerging demands of the 21st century.