It presents a compilation of studies that highlight the emergence of new ways of understanding, analyzing and transforming reality through scientific knowledge. This volume emphasizes the relevance of innovative, hybrid and expanding approaches that emerge in response to dynamic contexts, emerging issues and socio-cultural transformations. The collected articles explore how unconventional knowledges, alternative epistemologies and flexible methodologies contribute to the strengthening of critical thinking, epistemic inclusion and the generation of creative solutions. From technology and education to health, management and social sciences, proposals that enrich the scientific landscape with disruptive and contextually sensitive perspectives are evidenced. This issue invites reflection on the need to open the academic field to new ways of producing and validating knowledge, reaffirming the value of epistemic diversity in contemporary research.